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GLI2 Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession P10070
Additional Information
Gene ID 2736
Other Names Zinc finger protein GLI2, GLI family zinc finger protein 2 {ECO:0000312|HGNC:HGNC:4318}, Tax helper protein, GLI2 (HGNC:4318)
Target/Specificity The synthetic peptide sequence is selected from aa 1287-1301 of HUMAN GLI2 (HGNC:4318)
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLI2 (HGNC:4318)
Function Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. May play a role during embryogenesis.
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q0VGT2}. Cytoplasm {ECO:0000250|UniProtKB:Q0VGT2}. Note=In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus {ECO:0000250|UniProtKB:Q0VGT2} Isoform 2: Nucleus
Tissue Location Isoform 1 and isoform 4 are expressed in HTLV- 1-infected T-cell lines (at protein level). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines. Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines.
Research Areas
Citations (0)

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Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Is involved in the smoothened (SHH) signaling pathway.


Tanimura A.,et al.J. Virol. 72:3958-3964(1998).
Roessler E.,et al.Hum. Mol. Genet. 14:2181-2188(2005).
Hillier L.W.,et al.Nature 434:724-731(2005).
Tanimura A.,et al.J. Virol. 67:5375-5382(1993).
Ruppert J.M.,et al.Mol. Cell. Biol. 8:3104-3113(1988).

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$ 80.00
$ 99.00
Cat# BP20619c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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