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DHFR Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession P00374
Other Accession P00377, P00375, P00376
Additional Information
Gene ID 1719
Other Names Dihydrofolate reductase, DHFR
Target/Specificity The synthetic peptide sequence is selected from aa 16-50 of HUMAN DHFR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DHFR
Function Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.
Tissue Location Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood Expression is higher in the adult brain than in the fetal brain
Research Areas
Citations (0)

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Background

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.

References

Chen M.-J.,et al.J. Biol. Chem. 259:3933-3943(1984).
Masters J.N.,et al.Gene 21:59-63(1983).
Yang J.K.,et al.J. Mol. Biol. 176:169-187(1984).
Schmutz J.,et al.Nature 431:268-274(2004).
Banka S.,et al.Am. J. Hum. Genet. 88:216-225(2011).

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$ 80.00
$ 99.00
Cat# BP20626a
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