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PIP4K2C Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q8TBX8
Other Accession O88370, Q91XU3, Q0P5F7
Additional Information
Gene ID 79837
Other Names Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma, Phosphatidylinositol 5-phosphate 4-kinase type II gamma, PI(5)P 4-kinase type II gamma, PIP4KII-gamma, PIP4K2C, PIP5K2C
Target/Specificity The synthetic peptide sequence is selected from aa 23-37 of HUMAN PIP4K2C
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PIP4K2C (HGNC:23786)
Synonyms PIP5K2C
Function Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin- dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).
Cellular Location Endoplasmic reticulum {ECO:0000250|UniProtKB:O88370}. Cytoplasm {ECO:0000250|UniProtKB:O88370}
Research Areas
Citations (0)
citation

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Background

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum (By similarity).

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Daub H.,et al.Mol. Cell 31:438-448(2008).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).

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$ 277.78
Cat# BP20635a
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