|Other Names||Embryonic growth/differentiation factor 1, GDF-1, GDF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2063a was selected from the N-term region of human GDF1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May mediate cell differentiation events during embryonic development.|
|Tissue Location||Expressed in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
GDF1 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right assymetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA which also encodes the longevity assurance gene.
Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000).Jiang, J.C., et al., Genome Res. 8(12):1259-1272 (1998).Polymeropoulos, M.H., et al., Nat. Genet. 4(4):381-386 (1993).Lee, S.J., Proc. Natl. Acad. Sci. U.S.A. 88(10):4250-4254 (1991).
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