TUFM Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P49411 |
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Other Accession | P85834, Q8BFR5, P49410 |
Gene ID | 7284 |
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Other Names | Elongation factor Tu, mitochondrial, EF-Tu, P43, TUFM |
Target/Specificity | The synthetic peptide sequence is selected from aa 112-127 of HUMAN TUFM |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TUFM |
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Function | Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. |
Cellular Location | Mitochondrion. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
References
Woriax V.L.,et al.Biochim. Biophys. Acta 1264:347-356(1995).
Wells J.,et al.FEBS Lett. 358:119-125(1995).
Ling M.,et al.Gene 197:325-336(1997).
Martin J.,et al.Nature 432:988-994(2004).
Dunn M.J.,et al.Submitted (MAR-1996) to UniProtKB.
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