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DANRE pou5f1 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q90270
Additional Information
Gene ID 30333
Other Names POU domain, class 5, transcription factor 1, POU domain protein 2, pou5f1, gp-9, pou-2, pou2
Target/Specificity The synthetic peptide sequence is selected from aa 128-141 of HUMAN pou5f1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name pou5f1
Synonyms gp-9, pou-2, pou2
Function Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t- POU2 causes developmental retardation or arrest before gastrulation.
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t- POU2 causes developmental retardation or arrest before gastrulation.

References

Takeda H.,et al.Genes Dev. 8:45-59(1994).
Hauptmann G.,et al.Mech. Dev. 51:127-138(1995).

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$ 80.00
Cat# BP20644b
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