|Other Names||Growth/differentiation factor 2, GDF-2, Bone morphogenetic protein 9, BMP-9, GDF2, BMP9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2064a was selected from the N-term region of human GDF2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.|
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Provided below are standard protocols that you may find useful for product applications.
GDF2 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.
Majumdar, M.K., et al., J. Cell. Physiol. 189(3):275-284 (2001).Lopez-Coviella, I., et al., Science 289(5477):313-316 (2000).Miller, A.F., et al., J. Biol. Chem. 275(24):17937-17945 (2000).
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