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RCVRN Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession P35243
Other Accession P34057
Additional Information
Gene ID 5957
Other Names Recoverin, Cancer-associated retinopathy protein, Protein CAR, RCVRN, RCV1
Target/Specificity The synthetic peptide sequence is selected from aa 137-151 of HUMAN RCVRN
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCVRN
Synonyms RCV1
Function Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity).
Cellular Location Photoreceptor inner segment {ECO:0000250|UniProtKB:P34057}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P34057}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon {ECO:0000250|UniProtKB:P34057}. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity) {ECO:0000250|UniProtKB:P21457, ECO:0000250|UniProtKB:P34057}
Tissue Location Retina and pineal gland.
Research Areas
Citations (0)
citation

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Background

Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.

References

Murakami A.,et al.Biochem. Biophys. Res. Commun. 187:234-244(1992).
Wiechmann A.F.,et al.Exp. Eye Res. 56:463-470(1993).
Thirkill C.E.,et al.Invest. Ophthalmol. Vis. Sci. 33:2768-2772(1992).
Matsubara S.,et al.Br. J. Cancer 74:1419-1422(1996).
Polans A.S.,et al.J. Cell Biol. 112:981-989(1991).

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$ 277.78
Cat# BP20666c
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