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REG3A Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q06141 |
|---|
| Gene ID | 5068 |
|---|---|
| Other Names | Regenerating islet-derived protein 3-alpha, REG-3-alpha, Hepatointestinal pancreatic protein, HIP/PAP, Human proislet peptide, Pancreatitis-associated protein 1, Regenerating islet-derived protein III-alpha, Reg III-alpha, Regenerating islet-derived protein 3-alpha 165 kDa form, Regenerating islet-derived protein 3-alpha 15 kDa form, REG3A, HIP, PAP, PAP1 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 105-119 of HUMAN REG3A |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | REG3A (HGNC:8601) |
|---|---|
| Function | [Regenerating islet-derived protein 3-alpha 15 kDa form]: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan (PubMed:16931762). Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore (PubMed:24256734). |
| Cellular Location | Secreted. Note=Found in the apical region of pancreatic acinar cells |
| Tissue Location | Expressed by keratinocytes (PubMed:27830702). Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level) (PubMed:22727489). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis (PubMed:1469087). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
References
Itoh T.,et al.Biochim. Biophys. Acta 1172:184-186(1993).
Orelle B.,et al.J. Clin. Invest. 90:2284-2291(1992).
Lasserre C.,et al.Cancer Res. 52:5089-5095(1992).
Dusetti N.J.,et al.Genomics 19:108-114(1994).
Lasserre C.,et al.Eur. J. Biochem. 224:29-38(1994).
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