|Other Names||Growth/differentiation factor 3, GDF-3, GDF3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2066c was selected from the Center region of human GDF3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
GDF3 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. The function of this protein is unknown, but expression studies suggest it may be involved in regulation of the adult lymphatic and erythroid systems and embryonic development.
Clark, H.F., et al., Genome Res. 13(10):2265-2270 (2003).Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000).Caricasole, A.A., et al., Oncogene 16(1):95-103 (1998).
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