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GDF3 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NR23
Peptide ID 26348
Additional Information
Gene ID 9573
Other Names Growth/differentiation factor 3, GDF-3, GDF3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF3
Function Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089).
Cellular Location Secreted. Cytoplasm Note=Mainly accumulated in the cytoplasm
Research Areas
Citations (0)

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Background

GDF3 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues.

References

Ye, M., et al. Hum. Mol. Genet. 19(2):287-298(2010)Gopalan, A., et al. Mod. Pathol. 22(8):1066-1074(2009)Levine, A.J., et al. Dev. Biol. 325(1):43-48(2009)

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$ 80.00
Cat# BP2066d
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