ZNF830 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96NB3 |
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Gene ID | 91603 |
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Other Names | Zinc finger protein 830, Coiled-coil domain-containing protein 16, ZNF830, CCDC16 |
Target/Specificity | The synthetic peptide sequence is selected from aa 173-187 of HUMAN ZNF830 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ZNF830 (HGNC:28291) |
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Function | May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity). |
Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:Q8R1N0}. Nucleus speckle {ECO:0000250|UniProtKB:Q8R1N0}. Note=Excluded from nucleolus {ECO:0000250|UniProtKB:Q8R1N0} |
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Provided below are standard protocols that you may find useful for product applications.
Background
May act as a regulator of the cell cycle in embryos by participating in control of M phase (By similarity).
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Olsen J.V.,et al.Cell 127:635-648(2006).
Matsuoka S.,et al.Science 316:1160-1166(2007).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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