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FIS1 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q9Y3D6
Additional Information
Gene ID 51024
Other Names Mitochondrial fission 1 protein, FIS1 homolog, hFis1, Tetratricopeptide repeat protein 11, TPR repeat protein 11, FIS1, TTC11
Target/Specificity The synthetic peptide sequence is selected from aa 6-20 of HUMAN FIS1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FIS1
Synonyms TTC11
Function Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:12783892, PubMed:12861026, PubMed:14996942, PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:12861026, PubMed:16118244, PubMed:23283981, PubMed:23530241, PubMed:24196833). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (PubMed:23530241, PubMed:24196833). Also mediates peroxisomal fission (PubMed:16107562). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (PubMed:24196833). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (PubMed:12783892).
Cellular Location Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein
Research Areas
Citations (0)
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Background

Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

References

Lai C.-H.,et al.Genome Res. 10:703-713(2000).
Hillier L.W.,et al.Nature 424:157-164(2003).
Bienvenut W.V.,et al.Submitted (JUN-2005) to UniProtKB.
James D.I.,et al.J. Biol. Chem. 278:36373-36379(2003).
Yoon Y.,et al.Mol. Cell. Biol. 23:5409-5420(2003).

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$ 277.78
Cat# BP20678a
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