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GDF5 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P43026
Other Accession NP_000548
Clone Names 2081008
Peptide ID 2081008
Additional Information
Gene ID 8200
Other Names Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, BMP-14, Cartilage-derived morphogenetic protein 1, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, LPS-associated protein 4, Radotermin, GDF5, BMP14, CDMP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2067a was selected from the N-term region of human GDF5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF5
Synonyms BMP14, CDMP1
Function Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205).
Cellular Location Secreted. Cell membrane
Tissue Location Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level)
Research Areas
Citations (0)

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GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.


Kusafuka, K., et al., Virchows Arch. 442(5):482-490 (2003).Faiyaz-Ul-Haque, M., et al., Am. J. Med. Genet. 111(1):31-37 (2002).Everman, D.B., et al., Am. J. Med. Genet. 112(3):291-296 (2002).Faiyaz-Ul-Haque, M., et al., Clin. Genet. 61(6):454-458 (2002).Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000).

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$ 80.00
Cat# BP2067a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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