|Other Names||Growth/differentiation factor 8, GDF-8, Myostatin, MSTN, GDF8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2068a was selected from the N-term region of human GDF8 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts specifically as a negative regulator of skeletal muscle growth.|
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Provided below are standard protocols that you may find useful for product applications.
GDF8 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
Hill, J.J., et al., J. Biol. Chem. 277(43):40735-40741 (2002).Hamrick, M.W., et al., Calcif. Tissue Int. 71(1):63-68 (2002).Welle, S., et al., Exp. Gerontol. 37(6):833-839 (2002).Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000).Ferrell, R.E., et al., Genomics 62(2):203-207 (1999).
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