|Other Names||Mitochondrial import inner membrane translocase subunit TIM50, TIMM50, TIM50|
|Target/Specificity||The synthetic peptide sequence is selected from aa 25-36 of HUMAN TIMM50|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body.|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein|
|Tissue Location||Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body.
Guo Y.,et al.J. Biol. Chem. 279:24813-24825(2004).
Zheng H.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Zhang C.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (JUN-2005) to UniProtKB.
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