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GSN Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession P06396
Additional Information
Gene ID 2934
Other Names Gelsolin, AGEL, Actin-depolymerizing factor, ADF, Brevin, GSN
Target/Specificity The synthetic peptide sequence is selected from aa 36-50 of HUMAN GSN
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSN
Function Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Cellular Location Isoform 2: Cytoplasm, cytoskeleton.
Tissue Location Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells
Research Areas
Citations (0)

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Background

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.

References

Kwiatkowski D.J.,et al.Nature 323:455-458(1986).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).

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$ 80.00
Cat# BP20726a
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