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OPA1(form S1) Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession O60313
Other Accession Q2TA68, P58281, Q5U3A7, Q5F499
Additional Information
Gene ID 4976
Other Names Dynamin-like 120 kDa protein, mitochondrial, Optic atrophy protein 1, Dynamin-like 120 kDa protein, form S1, OPA1, KIAA0567
Target/Specificity The synthetic peptide sequence is selected from aa 895-909 of HUMAN OPA1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name OPA1
Synonyms KIAA0567
Function Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. May also play a role in mitochondrial genome maintenance.
Cellular Location Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space
Tissue Location Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues.
Research Areas
Citations (0)

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Background

Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space.

References

Nagase T.,et al.DNA Res. 5:31-39(1998).
Wang W.,et al.Nucleic Acids Res. 39:44-58(2011).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Delettre C.,et al.Hum. Genet. 109:584-591(2001).

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$ 80.00
$ 99.00
Cat# BP20727c
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