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CPLX2 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6PUV4 |
|---|---|
| Other Accession | P84087, P84086, P84088 |
| Gene ID | 10814 |
|---|---|
| Other Names | Complexin-2, Complexin II, CPX II, Synaphin-1, CPLX2 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 51-63 of HUMAN CPLX2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CPLX2 |
|---|---|
| Function | Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity). |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P84087}. Presynapse {ECO:0000250|UniProtKB:P84087}. Nucleus {ECO:0000250|UniProtKB:P84087} Perikaryon {ECO:0000250|UniProtKB:P84087}. Note=Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation. {ECO:0000250|UniProtKB:P84087} |
| Tissue Location | Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in synaptic vesicle exocytosis. Also involved in mast cell exocytosis (By similarity).
References
McMahon H.T.,et al.Cell 83:111-119(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Raevskaya N.M.,et al.Gene 359:127-137(2005).
Harrison P.J.,et al.Lancet 352:1669-1673(1998).
Eastwood S.L.,et al.Brain Res. Bull. 55:569-578(2001).
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