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PHB Blocking Peptide (N-term)

Synthetic peptide

     
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  • CITATIONS
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Product Information
Primary Accession P35232
Other Accession P67779, P67778, Q3T165, P24156
Additional Information
Gene ID 5245
Other Names Prohibitin, PHB
Target/Specificity The synthetic peptide sequence is selected from aa 73-87 of HUMAN PHB
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHB1 {ECO:0000303|PubMed:28017329, ECO:0000312|HGNC:HGNC:8912}
Function Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity).
Cellular Location Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane
Tissue Location Widely expressed in different tissues.
Research Areas
Citations (0)
citation

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Background

Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

References

Sato T.,et al.Cancer Res. 52:1643-1646(1992).
Sato T.,et al.Genomics 17:762-764(1993).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Bienvenut W.V.,et al.Submitted (MAR-2005) to UniProtKB.
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.

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$ 277.78
Cat# BP20757a
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