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SYCP3 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q8IZU3
Additional Information
Gene ID 50511
Other Names Synaptonemal complex protein 3, SCP-3, SYCP3, SCP3
Target/Specificity The synthetic peptide sequence is selected from aa 13-26 of HUMAN SYCP3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYCP3
Synonyms SCP3
Function Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q60547}. Chromosome {ECO:0000250|UniProtKB:Q60547}. Chromosome, centromere {ECO:0000250|UniProtKB:Q60547}. Note=It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres {ECO:0000250|UniProtKB:Q60547}
Tissue Location Testis-specific.
Research Areas
Citations (0)

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Background

Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).

References

Martinez-Garay I.,et al.Genomics 80:259-267(2002).
Adamah D.J.B.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Miyamoto T.,et al.Lancet 362:1714-1719(2003).

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$ 80.00
Cat# BP20774a
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