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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   ZNF423 Blocking Peptide (Center)   

ZNF423 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q2M1K9
Other Accession O08961, Q80TS5
Additional Information
Gene ID 23090
Other Names Zinc finger protein 423, Olf1/EBF-associated zinc finger protein, hOAZ, Smad- and Olf-interacting zinc finger protein, ZNF423, KIAA0760, NPHP14, OAZ
Target/Specificity The synthetic peptide sequence is selected from aa 864-877 of HUMAN ZNF423
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNF423
Synonyms KIAA0760, NPHP14, OAZ
Function Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
Cellular Location Nucleus.
Tissue Location Expressed in brain, lung, skeletal muscle, heart, pancreas and kidney but not liver or placenta. Also expressed in aorta, ovary, pituitary, small intestine, fetal brain, fetal kidney and, within the adult brain, in the substantia nigra, medulla, amygdala, thalamus and cerebellum
Research Areas
Citations (0)

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Background

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.

References

Hata A.,et al.Cell 100:229-240(2000).
Nagase T.,et al.DNA Res. 5:277-286(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Rigbolt K.T.,et al.Sci. Signal. 4:RS3-RS3(2011).
Chaki M.,et al.Cell 150:533-548(2012).

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$ 80.00
Cat# BP20776c
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