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HUMAN-RIN1(Y36) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q13671
Additional Information
Gene ID 9610
Other Names Ras and Rab interactor 1, Ras inhibitor JC99, Ras interaction/interference protein 1, RIN1
Target/Specificity The synthetic peptide sequence is selected from aa 20-50 of HUMAN RIN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RIN1
Function Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
Cellular Location Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane- associated
Tissue Location Expressed in all tissues examined with high levels in brain, placenta and pancreas
Research Areas
Citations (0)

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Background

Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

References

Colicelli J.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:2913-2917(1991).
Han L.,et al.Mol. Cell. Biol. 15:1318-1323(1995).
Han L.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:4954-4959(1997).
Afar D.E.H.,et al.Immunity 6:773-782(1997).
Tall G.G.,et al.Dev. Cell 1:73-82(2001).

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$ 80.00
Cat# BP20829a
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