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KCNJ16 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NPI9 |
|---|---|
| Other Accession | P52191, Q9Z307 |
| Gene ID | 3773 |
|---|---|
| Other Names | Inward rectifier potassium channel 16, Inward rectifier K(+) channel Kir51, Potassium channel, inwardly rectifying subfamily J member 16, KCNJ16 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 286-299 of HUMAN KCNJ16 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KCNJ16 |
|---|---|
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201). |
| Cellular Location | Membrane; Multi- pass membrane protein. Basolateral cell membrane. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10 |
| Tissue Location | Widely expressed, with highest levels in adult and fetal kidney (at protein level). In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance.
References
Liu Y.,et al.Cytogenet. Cell Genet. 90:60-63(2000).
Derst C.,et al.FEBS Lett. 491:305-311(2001).
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