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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   (Mouse) Sox17 Blocking Peptide (C-term)   

(Mouse) Sox17 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q61473
Additional Information
Gene ID 20671
Other Names Transcription factor SOX-17, Sox17, Sox-17
Target/Specificity The synthetic peptide sequence is selected from aa 376-389 of HUMAN Sox17
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Sox17
Synonyms Sox-17
Function Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Isoform 2 (T-SOX17) shows no DNA-binding activity.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:20802155}
Tissue Location Testis. Detected in lung.
Research Areas
Citations (0)

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Background

Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells. Isoform 2 (T-SOX17) shows no DNA-binding activity.

References

Kanai Y.,et al.J. Cell Biol. 133:667-681(1996).
Carninci P.,et al.Science 309:1559-1563(2005).
Layfield R.,et al.Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases.
Kanai-Azuma M.,et al.Development 129:2367-2379(2002).
Kim I.,et al.Cell 130:470-483(2007).

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$ 80.00
$ 99.00
Cat# BP20861c
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