LIPI Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6XZB0 |
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Gene ID | 149998 |
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Other Names | Lipase member I, LIPI, 311-, Cancer/testis antigen 17, CT17, LPD lipase, Membrane-associated phosphatidic acid-selective phospholipase A1-beta, mPA-PLA1 beta, LIPI, LPDL |
Target/Specificity | The synthetic peptide sequence is selected from aa 224-238 of HUMAN LIPI |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LIPI |
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Synonyms | LPDL |
Function | Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). |
Cellular Location | [Isoform 1]: Cell membrane. Secreted Note=May associate with lipid draft. |
Tissue Location | Expressed in testis. Expressed exclusively at the connecting piece of the sperm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
References
Hiramatsu T.,et al.J. Biol. Chem. 278:49438-49447(2003).
Wen X.-Y.,et al.Hum. Mol. Genet. 12:1131-1143(2003).
Hattori M.,et al.Nature 405:311-319(2000).
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