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ROS1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession P08922
Additional Information
Gene ID 6098
Other Names Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor tyrosine kinase c-ros oncogene 1, c-Ros receptor tyrosine kinase, ROS1, MCF3, ROS
Target/Specificity The synthetic peptide sequence is selected from aa 1744-1757 of HUMAN ROS1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ROS1
Synonyms MCF3, ROS
Function Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in brain. Expression is increased in primary gliomas.
Research Areas
Citations (0)
citation

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Background

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

References

Birchmeier C.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:4799-4803(1990).
Mungall A.J.,et al.Nature 425:805-811(2003).
Matsushime H.,et al.Mol. Cell. Biol. 6:3000-3004(1986).
Birchmeier C.,et al.Mol. Cell. Biol. 6:3109-3116(1986).
Watkins D.,et al.Cancer Genet. Cytogenet. 72:130-136(1994).

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$ 277.78
Cat# BP20883c
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