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(Mouse) Mlf1 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q9QWV4
Additional Information
Gene ID 17349
Other Names Myeloid leukemia factor 1, Hematopoietic lineage switch 7, Myelodysplasia-myeloid leukemia factor 1, Mlf1, Hls7
Target/Specificity The synthetic peptide sequence is selected from aa 91-106 of HUMAN Mlf1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mlf1
Synonyms Hls7
Function Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus.
Tissue Location Highly expressed in skeletal muscle, heart, testis. Also found in lung, but not in spleen, thymus, bone marrow, liver and kidney.
Research Areas
Citations (0)

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Background

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

References

Hitzler J.K.,et al.Am. J. Pathol. 155:53-59(1999).
Williams J.H.,et al.EMBO J. 18:5559-5566(1999).
Lim R.,et al.J. Biol. Chem. 277:40997-41008(2002).
Winteringham L.N.,et al.Oncogene 23:5105-5109(2004).
Winteringham L.N.,et al.J. Biol. Chem. 281:38791-38800(2006).

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$ 80.00
Cat# BP20887a
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