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(Mouse) Trim24 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q64127 |
|---|
| Gene ID | 21848 |
|---|---|
| Other Names | Transcription intermediary factor 1-alpha, TIF1-alpha, 632-, E3 ubiquitin-protein ligase Trim24, Tripartite motif-containing protein 24, Trim24, Tif1, Tif1a |
| Target/Specificity | The synthetic peptide sequence is selected from aa 789-823 of HUMAN Trim24 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Trim24 |
|---|---|
| Synonyms | Tif1, Tif1a |
| Function | Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes. |
| Cellular Location | Nucleus. Cytoplasm. Note=Detected in the cytoplasm of the zygote (PubMed:16880268). Translocates into the pronucleus at the time of genome activation (PubMed:16880268). Colocalizes with sites of active transcription (PubMed:10610177). Localizes to sites of DNA damage (By similarity). {ECO:0000250|UniProtKB:O15164, ECO:0000269|PubMed:10610177, ECO:0000269|PubMed:16880268} |
| Tissue Location | Detected in embryonic and adult liver. Detected in zygote and throughout embryogenesis (at protein level). Detected in all adult tissues, with the highest expression level in testis |
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Background
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53 levels. Up-regulates ligand- dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, such as RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Required for normal transition from proliferating neonatal hepatocytes to quiescent adult hepatocytes.
References
le Douarin B.,et al.EMBO J. 14:2020-2033(1995).
le Douarin B.,et al.EMBO J. 15:6701-6715(1996).
Zhong S.,et al.Nat. Genet. 23:287-295(1999).
Seeler J.-S.,et al.Mol. Cell. Biol. 21:3314-3324(2001).
Torres-Padilla M.E.,et al.J. Cell Biol. 174:329-338(2006).
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