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SMG7 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q92540
Other Accession Q5RJH6
Additional Information
Gene ID 9887
Other Names Protein SMG7, EST1-like protein C, SMG-7 homolog, hSMG-7, SMG7, C1orf16, EST1C, KIAA0250
Target/Specificity The synthetic peptide sequence is selected from aa 896-910 of HUMAN SMG7
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMG7
Synonyms C1orf16, EST1C, KIAA0250
Function Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm
Research Areas
Citations (0)

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Background

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.

References

Ohnishi T.,et al.Mol. Cell 12:1187-1200(2003).
Nagase T.,et al.DNA Res. 3:321-329(1996).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 80.00
$ 99.00
Cat# BP20918c
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