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MOUSE Bcar3 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9QZK2 |
|---|
| Gene ID | 29815 |
|---|---|
| Other Names | Breast cancer anti-estrogen resistance protein 3, p130Cas-binding protein AND-34, Bcar3, And34 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 785-798 of HUMAN Bcar3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Bcar3 |
|---|---|
| Synonyms | And34 |
| Function | Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:12517963). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:10896938). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (PubMed:25499443). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (PubMed:25499443). Regulates EGF-induced DNA synthesis (By similarity). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (PubMed:19365570). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (PubMed:22801373). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (PubMed:22801373). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (PubMed:10896938). However, in a contrasting study, lacks GEF activity towards RAP1 (By similarity). |
| Cellular Location | Cytoplasm. Cell junction, focal adhesion Note=Localization to focal adhesions depends on interaction with PTPRA |
| Tissue Location | Abundantly expressed in the lung and brain, with lower expression in splenic lymphocytes and liver (at protein level) (PubMed:19365570). Expressed in splenic lymphocytes (at protein level) (PubMed:19365570). Expressed in the lymph node cortical region, periphery of the splenic white pulp and in alveolar lung fibroblasts (PubMed:19365570). Expressed in epithelial cells in the lens equatorial region and early stage nucleated cortical lens fiber cells (PubMed:19365570). Expressed in the thymus (PubMed:10438950). Expressed in B-cells (PubMed:12517963). |
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Provided below are standard protocols that you may find useful for product applications.
Background
May act as an adapter protein and couple activated growth factor receptors to signaling molecules that regulate src kinase activity and promote cell migration.
References
Cai D.,et al.J. Immunol. 163:2104-2112(1999).
Carninci P.,et al.Science 309:1559-1563(2005).
Gotoh T.,et al.J. Biol. Chem. 275:30118-30123(2000).
Cai D.,et al.J. Immunol. 170:969-978(2003).
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