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IHH Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q14623
Additional Information
Gene ID 3549
Other Names Indian hedgehog protein, IHH, HHG-2, Indian hedgehog protein N-product, Indian hedgehog protein C-product, IHH
Target/Specificity The synthetic peptide sequence is selected from aa 397-411 of HUMAN IHH
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IHH
Function Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).
Cellular Location Indian hedgehog protein N-product: Cell membrane; Lipid-anchor; Extracellular side. Note=The N-terminal peptide remains associated with the cell surface. Cell membrane.
Tissue Location Expressed in embryonic lung, and in adult kidney and liver
Research Areas
Citations (0)

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Background

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).

References

Tate G.,et al.J. Biochem. Mol. Biol. Biophys. 4:27-34(2000).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Marigo V.,et al.Genomics 28:44-51(1995).
Chang D.T.,et al.Development 120:3339-3353(1994).
Pepinsky R.B.,et al.J. Biol. Chem. 273:14037-14045(1998).

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$ 80.00
Cat# BP20973c
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