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Mouse Myocd Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8VIM5 |
|---|---|
| Other Accession | Q8R5I7, Q7YR76, Q8IZQ8 |
| Gene ID | 214384 |
|---|---|
| Other Names | Myocardin, Basic SAP coiled-coil transcription activator 2, SRF cofactor protein, Myocd, Bsac2, Mycd, Srfcp |
| Target/Specificity | The synthetic peptide sequence is selected from aa 743-757 of HUMAN Myocd |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Myocd |
|---|---|
| Synonyms | Bsac2, Mycd, Srfcp |
| Function | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). |
| Cellular Location | Nucleus speckle. Note=Nuclear, with a punctate intranuclear pattern with exclusion from nuclei |
| Tissue Location | Expressed in smooth muscle cell-containing tissues (PubMed:12663482). Expressed in the heart (PubMed:11439182, PubMed:14645532, PubMed:12640126, PubMed:12663482, PubMed:20385216) Expressed in the aorta and bladder (PubMed:12640126, PubMed:12663482, PubMed:20385216). Weakly expression in the lung, testis and kidney (PubMed:14645532). Weakly expressed in the stomach (PubMed:12640126, PubMed:12663482). Weakly expressed in the intestine and colon (PubMed:12663482). [Isoform 3]: Predominantly expressed in cardiac muscle. [Isoform 5]: Predominantly expressed in smooth muscle cell-rich tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.
References
Wang D.-Z.,et al.Cell 105:851-862(2001).
Wang D.-Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:14855-14860(2002).
Ueyama T.,et al.Mol. Cell. Biol. 23:9222-9232(2003).
Sawada T.,et al.Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
Du K.L.,et al.Mol. Cell. Biol. 23:2425-2437(2003).
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