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(Mouse) Smad2 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q62432
Other Accession P84025, P84024, Q8BUN5, P84022, P84023, O70436, Q15796, Q1W668
Additional Information
Gene ID 17126
Other Names Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, Mad-related protein 2, mMad2, SMAD family member 2, SMAD 2, Smad2, Smad2, Madh2, Madr2
Target/Specificity The synthetic peptide sequence is selected from aa 198-212 of HUMAN Smad2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Smad2
Synonyms Madh2, Madr2
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (PubMed:33548622). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 (PubMed:21145499, PubMed:33548622). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (By similarity). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (PubMed:21145499). {ECO:0000250|UniProtKB:Q15796, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:33548622}
Research Areas
Citations (0)
citation

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Background

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).

References

Baker J.C.,et al.Genes Dev. 10:1880-1889(1996).
Devereux T.R.,et al.Carcinogenesis 18:1751-1755(1997).
Bernard D.J.,et al.Mol. Endocrinol. 18:606-623(2004).
Carninci P.,et al.Science 309:1559-1563(2005).
Weinstein M.,et al.Cytokine Growth Factor Rev. 11:49-58(2000).

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$ 277.78
Cat# BP21006a
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