NACC1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96RE7 |
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Gene ID | 112939 |
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Other Names | Nucleus accumbens-associated protein 1, NAC-1, BTB/POZ domain-containing protein 14B, NACC1, BTBD14B, NAC1 |
Target/Specificity | The synthetic peptide sequence is selected from aa 324-338 of HUMAN NACC1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NACC1 |
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Synonyms | BTBD14B, NAC1 |
Function | Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. |
Cellular Location | Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation. |
Tissue Location | Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer. |
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Background
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
References
Cha X.Y.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Nakayama K.,et al.Proc. Natl. Acad. Sci. U.S.A. 103:18739-18744(2006).
Nakayama K.,et al.Cancer Res. 67:8058-8064(2007).
Davidson B.,et al.Hum. Pathol. 38:1030-1036(2007).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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