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NTRK3 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q16288
Other Accession P24786, Q5IFJ9
Additional Information
Gene ID 4916
Other Names NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, NTRK3, TRKC
Target/Specificity The synthetic peptide sequence is selected from aa 393-406 of HUMAN NTRK3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTRK3
Synonyms TRKC
Function Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain
Research Areas
Citations (0)

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Background

Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

References

McGregor L.M.,et al.Genomics 22:267-272(1994).
Shelton D.L.,et al.J. Neurosci. 15:477-491(1995).
Ichaso N.,et al.Oncogene 17:1871-1875(1998).
Ultsch M.H.,et al.J. Mol. Biol. 290:149-159(1999).
Greenman C.,et al.Nature 446:153-158(2007).

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$ 80.00
Cat# BP21038a
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