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HEMGN Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q9BXL5
Additional Information
Gene ID 55363
Other Names Hemogen, Erythroid differentiation-associated gene protein, EDAG-1, Hemopoietic gene protein, Negative differentiation regulator protein, HEMGN, EDAG, NDR
Target/Specificity The synthetic peptide sequence is selected from aa 355-369 of HUMAN HEMGN
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HEMGN
Synonyms EDAG, NDR
Function Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
Cellular Location Nucleus.
Tissue Location Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia.
Research Areas
Citations (0)

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Background

Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).

References

Yang L.V.,et al.Mech. Dev. 104:105-111(2001).
Yang L.V.,et al.Dev. Dyn. 228:606-616(2003).
Li C.Y.,et al.Cell Death Differ. 11:1299-1308(2004).
Liu C.C.,et al.J. Biomed. Sci. 11:104-116(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).

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$ 80.00
$ 99.00
Cat# BP21062a
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