|Other Names||E3 ubiquitin-protein ligase RNF216, 632-, RING finger protein 216, Triad domain-containing protein 3, Ubiquitin-conjugating enzyme 7-interacting protein 1, Zinc finger protein inhibiting NF-kappa-B, RNF216, TRIAD3, UBCE7IP1, ZIN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2106a was selected from the N-term region of human UBCE7IP1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||TRIAD3, UBCE7IP1, ZIN|
|Function||Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.|
|Tissue Location||Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes|
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UBCE7IP1 might act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. It inhibits TNF and IL-1 mediated activation of NF-kappa-B, and promotes TNF and RIP mediated apoptosis. Evidence exists to suggest an interaction with UBE2L3 and RIPK1. Expression is ubiquitous, with the highest levels in testis and peripheral blood leukocytes. Structurally, the protein contains a putative 1 IBR-type zinc finger and 2 RING-type zinc fingers.
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).Chen, D., et al., J. Biol. Chem. 277(18):15985-15991 (2002).Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
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