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TJP1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q07157
Additional Information
Gene ID 7082
Other Names Tight junction protein ZO-1, Tight junction protein 1, Zona occludens protein 1, Zonula occludens protein 1, TJP1, ZO1
Target/Specificity The synthetic peptide sequence is selected from aa 1328-1342 of HUMAN TJP1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TJP1
Synonyms ZO1
Function The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells
Tissue Location The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules
Research Areas
Citations (0)

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Background

The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.

References

Willott E.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:7834-7838(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Cohen C.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:15191-15196(2001).
D'Atri F.,et al.J. Biol. Chem. 277:27757-27764(2002).

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$ 80.00
$ 99.00
Cat# BP21071a
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