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(DANRE) sh3bp4a Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q1LVQ2
Additional Information
Gene ID 403082
Other Names SH3 domain-binding protein 4-A, sh3bp4a, sh3bp4
Target/Specificity The synthetic peptide sequence is selected from aa 132-145 of HUMAN sh3bp4a
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name sh3bp4a
Synonyms sh3bp4
Function Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).
Cellular Location Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle Nucleus. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin- coated vesicles. May also localize to the nucleus (By similarity)
Research Areas
Citations (0)

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Background

Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).

References

Howe K.,et al.Nature 496:498-503(2013).
Abe S.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.

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$ 80.00
Cat# BP21084a
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