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Mouse Pax6 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P63015 |
|---|---|
| Other Accession | P55864, P63016, P26367, P26630, P47237, Q1LZF1 |
| Gene ID | 18508 |
|---|---|
| Other Names | Paired box protein Pax-6, Oculorhombin, Pax6, Pax-6, Sey |
| Target/Specificity | The synthetic peptide sequence is selected from aa 404-416 of HUMAN Pax6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Pax6 |
|---|---|
| Synonyms | Pax-6, Sey |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (PubMed:9163426). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (PubMed:23990468). |
| Cellular Location | Nucleus. [Isoform 3]: Nucleus. Cytoplasm |
| Tissue Location | Expressed in osteoclasts. [Isoform 3]: Dominant isoform expressed in the eye, including in the retina and cornea (PubMed:21084637). Weakly expressed in the lens epithelium (PubMed:21084637) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).
References
Walther C.,et al.Development 113:1435-1449(1991).
Favor J.,et al.Genetics 159:1689-1700(2001).
Carninci P.,et al.Science 309:1559-1563(2005).
Walther C.,et al.Genomics 11:424-434(1991).
Ton C.C.T.,et al.Genomics 13:251-256(1992).
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