|Other Accession||Q07917, Q06219, Q08E53|
|Other Names||Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor, NR4A2, NOT, NURR1, TINUR|
|Target/Specificity||The synthetic peptide sequence is selected from aa 380-392 of HUMAN NR4A2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||NOT, NURR1, TINUR|
|Function||Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization|
|Tissue Location||Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue|
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Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
Mages H.W.,et al.Mol. Endocrinol. 8:1583-1591(1994).
Ichinose H.,et al.Gene 230:233-239(1999).
Torii T.,et al.Gene 230:225-232(1999).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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