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PTPRZ1 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession P23471
Other Accession Q62656
Additional Information
Gene ID 5803
Other Names Receptor-type tyrosine-protein phosphatase zeta, R-PTP-zeta, Protein-tyrosine phosphatase receptor type Z polypeptide 1, Protein-tyrosine phosphatase receptor type Z polypeptide 2, R-PTP-zeta-2, PTPRZ1, HTPZP2, PTPRZ, PTPRZ2, PTPZ
Target/Specificity The synthetic peptide sequence is selected from aa 446-460 of HUMAN PTPRZ1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPRZ1
Synonyms HTPZP2, PTPRZ, PTPRZ2, PTPZ
Function Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is apparently generated by shedding of the extracellular domain
Tissue Location Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.
Research Areas
Citations (0)

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Background

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).

References

Krueger N.X.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7417-7421(1992).
Levy J.B.,et al.J. Biol. Chem. 268:10573-10581(1993).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 80.00
Cat# BP21103a
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