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Mouse Nkx2-5 Blocking Peptide (Center)

Synthetic peptide

     
  • SPECIFICATION
  • CITATIONS
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Product Information
Primary Accession P42582
Other Accession O35767
Additional Information
Gene ID 18091
Other Names Homeobox protein Nkx-25, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Nkx2-5, Csx, Nkx-25, Nkx2e
Target/Specificity The synthetic peptide sequence is selected from aa 192-205 of HUMAN Nkx2-5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Nkx2-5
Synonyms Csx, Nkx-2.5, Nkx2e
Function Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B. Together with PBX1, it is required for spleen development through a mechanism that involves CDKN2B repression.
Cellular Location Nucleus.
Tissue Location Predominantly in the adult and embryonic heart, and to a lesser extent in lingual muscle, spleen and stomach
Research Areas
Citations (0)

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Background

Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B. Together with PBX1, it is required for spleen development through a mechanism that involves CDKN2B repression.

References

Lints T.J.,et al.Development 119:419-431(1993).
Lints T.J.,et al.Development 119:969-969(1993).
Searcy R.D.,et al.Development 125:4461-4470(1998).
Komuro I.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:8145-8149(1993).
Kim Y.H.,et al.J. Biol. Chem. 273:25875-25879(1998).

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$ 80.00
Cat# BP21109a
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Availability: 2 weeks
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