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ZNF281 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q9Y2X9
Additional Information
Gene ID 23528
Other Names Zinc finger protein 281, GC-box-binding zinc finger protein 1, Transcription factor ZBP-99, Zinc finger DNA-binding protein 99, ZNF281, GZP1, ZBP99
Target/Specificity The synthetic peptide sequence is selected from aa 416-430 of HUMAN ZNF281
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNF281
Synonyms GZP1, ZBP99
Function Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.
Cellular Location Nucleus.
Research Areas
Citations (0)
citation

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Background

Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G- rich box in the enhancer region of these genes.

References

Law D.J.,et al.Biochem. Biophys. Res. Commun. 262:113-120(1999).
Lisowsky T.,et al.FEBS Lett. 453:369-374(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Zhang X.,et al.Nucleic Acids Res. 31:2900-2914(2003).

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$ 277.78
Cat# BP21118a
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Availability: 2 weeks
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