Mouse Frk Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q922K9 |
---|---|
Other Accession | Q62662 |
Gene ID | 14302 |
---|---|
Other Names | Tyrosine-protein kinase FRK, Beta-cell Src-homology tyrosine kinase, BSK, FYN-related kinase, Intestine tyrosine kinase, Frk, Bsk, Iyk |
Target/Specificity | The synthetic peptide sequence is selected from aa 476-489 of HUMAN Frk |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Frk |
---|---|
Synonyms | Bsk, Iyk |
Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity). |
Cellular Location | Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery. |
Tissue Location | Expressed in intestinal tract, fetal and adult islets of Langerhans, kidney, liver and lung |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
References
Thuveson M.,et al.Biochem. Biophys. Res. Commun. 209:582-589(1995).
Oberg-Welsh C.,et al.Gene 152:239-242(1995).
Carninci P.,et al.Science 309:1559-1563(2005).
Chandrasekharan S.,et al.Mol. Cell. Biol. 22:5235-5247(2002).
Welsh M.,et al.Biochem. J. 382:261-268(2004).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.