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(DANRE) gpr126 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | C6KFA3 |
|---|
| Gene ID | 561970 |
|---|---|
| Other Names | G-protein coupled receptor 126, gpr126 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 1135-1149 of HUMAN gpr126 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | adgrg6 |
|---|---|
| Synonyms | gpr126 |
| Function | G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins (PubMed:25118328). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:19745155). Also plays a role in inner ear development (PubMed:24067352). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in Schwann cells of the posterior lateral line nerve and in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor. Required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. Required for normal expression of the transcription factors oct6 and krox20 that are required for Schwann cells to inititate myelination.
References
Monk K.R.,et al.Science 325:1402-1405(2009).
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