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(DANRE) gpr126 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession C6KFA3
Additional Information
Gene ID 561970
Other Names G-protein coupled receptor 126, gpr126
Target/Specificity The synthetic peptide sequence is selected from aa 1135-1149 of HUMAN gpr126
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name gpr126
Function Orphan receptor. Required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. Required for normal expression of the transcription factors oct6 and krox20 that are required for Schwann cells to initiate myelination.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in Schwann cells of the posterior lateral line nerve and in brain.
Research Areas
Citations (0)

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Background

Orphan receptor. Required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. Required for normal expression of the transcription factors oct6 and krox20 that are required for Schwann cells to inititate myelination.

References

Monk K.R.,et al.Science 325:1402-1405(2009).

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$ 80.00
$ 99.00
Cat# BP21136a
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