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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   E1 Ubiquitin (UBE1) Antibody (Center) Blocking peptide   

E1 Ubiquitin (UBE1) Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P22314
Other Accession UBA1_HUMAN
Clone Names 3061603
Peptide ID 3061603
Additional Information
Gene ID 7317
Other Names Ubiquitin-like modifier-activating enzyme 1, Protein A1S9, Ubiquitin-activating enzyme E1, UBA1, A1S9T, UBE1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2113c was selected from the Center region of human UBE1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBA1
Synonyms A1S9T, UBE1
Function Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system. Activates ubiquitin by first adenylating its C- terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
Cellular Location Cytoplasm. Mitochondrion. Nucleus. Isoform 2: Cytoplasm.
Research Areas
Citations (0)

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UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternative splicing results in 2 transcript variants encoding the same protein, but with different 5' UTR.


Ayusawa, D., et al., Cell Struct. Funct. 17(2):113-122 (1992).Handley, P.M., et al., Proc. Natl. Acad. Sci. U.S.A. 88(1):258-262 (1991).Kudo, M., et al., Exp. Cell Res. 192(1):110-117 (1991).Zacksenhaus, E., et al., Cytogenet. Cell Genet. 53(1):20-22 (1990).Zacksenhaus, E., et al., EMBO J. 9(9):2923-2929 (1990).

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$ 80.00
Cat# BP2113c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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