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Mouse Nr5a2 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession P45448
Additional Information
Gene ID 26424
Other Names Nuclear receptor subfamily 5 group A member 2, Liver receptor homolog 1, LRH-1, Nr5a2, Lrh1
Target/Specificity The synthetic peptide sequence is selected from aa 200-213 of HUMAN Nr5a2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Nr5a2
Synonyms Lrh1
Function Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of cholesterol 7-alpha- hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
Cellular Location Nucleus {ECO:0000250|UniProtKB:O00482}.
Research Areas
Citations (0)

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Background

Binds to promoters containing the sequence element 5'- AACGACCGACCTTGAG-3'. Plays a role in the regulation of gene expression in liver and pancreas. May play a role in embryonic development (By similarity).

References

Tugwood J.D.,et al.Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
Sablin E.P.,et al.Mol. Cell 11:1575-1585(2003).
Li Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 102:9505-9510(2005).

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$ 80.00
Cat# BP21181c
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