GNL3 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BVP2 |
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Gene ID | 26354 |
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Other Names | Guanine nucleotide-binding protein-like 3, E2-induced gene 3 protein, Novel nucleolar protein 47, NNP47, Nucleolar GTP-binding protein 3, Nucleostemin, GNL3, E2IG3, NS |
Target/Specificity | The synthetic peptide sequence is selected from aa 91-104 of HUMAN GNL3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GNL3 |
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Synonyms | E2IG3, NS |
Function | May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q811S9}. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9} |
Tissue Location | Increased levels in lung tissue in cancer patients. |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
References
Charpentier A.H.,et al.Cancer Res. 60:5977-5983(2000).
Han C.,et al.Int. J. Mol. Med. 16:205-213(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Andersen J.S.,et al.Curr. Biol. 12:1-11(2002).
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